Dispelling nutrition myths, ranting, and occasionally, raving

Insane in the Grain Brain



My library hold finally came in! No way was I paying to read Grain Brain. I like to financially support quacks as little as possible.

First thought: Including a quote from Dr. Oz on the front cover of your book does little for your credibility.

Second thought: I really like the font used for the Contents page.

Introduction“I’m also a founding member and fellow of the American Board of Integrative and Holistic Medicine.” Cue alarm bells! He said the “H-word”! I promptly googled the organization to learn more. Hmm… While I like the general notion of treating the patient as a whole I’m not sure about this principle: “Integrative holistic physicians strive to relate to patients with grace, kindness and acceptance, emanating from the attitude of unconditional love as life’s most powerful healer.” Love as the most powerful healer?? Call me crazy but I’m not going to my doc for love to heal me when I have an injury or infection. For more about the ABIH check out this post on Science-Based Medicine. Which confirms my fear that this certification has essentially zero meaning. Okay… So the author, David Perlmutter, is the founder of a quack organization. Still, just for fun, I’ll keep reading and see what his “proof” regarding the toxicity of grains is.

Modern wheat is not the same as the wheat of our ancestors. Yeah, yeah. We’ve heard this all before.

“Why is precious little information made available about how we can keep our brains healthy and stave off brain diseases?” I do like this question. Also, I suspect the answer is the same for the brain as for other organs: get plenty of exercise, avoid being sedentary, cook for yourself, and eat more veg. Oh, wait. Not according to Perlmutter, “it’s pointless to consume antioxidants.” Forget the veg, apparently we should all be eating more fat and cholesterol.

Self-Assessment: Ooh! This should be fun! I got 7 out of 20. Zero is optimal but at least I’m not in the “hazard zone” which is anything over 10.

Chapter 1“As many as 40 percent of us can’t properly process gluten”. Reference please. Where did this figure come from and what precisely does inability to properly process gluten mean?

Yes, cholesterol is essential in our bodies. However, a dietary source of cholesterol is not essential. Our bodies can make it. Also, what does this have to do with grains being the cause of brain degeneration and diseases?

Chapter 2: I wonder what this “test for gluten sensitivity” he’s ordering for his patients is. I can’t dispute these tales of improvement in patients following elimination of gluten. However, it’s important to note that we don’t have all of the details and elimination of gluten may not have been the “cure” for migraines and bipolar disorder Perlmutter wants us to believe it is.

A lovely image of a brain scan of a “gluten sensitive” patient versus one of a “normal” patient shows extensive damage in the GS brain. Obviously, this is proof that gluten causes brain damage. Or is it? Remember, correlation does not equal causation. And one brain scan image does not mean gluten will destroy your brain.

In the chapter about gluten Perlmutter says, “one of the main reasons why consuming so many grains and carbs can be so harmful is that they raise blood sugar”. Huh? So the cause of brain disorders is gluten, which is a protein, which would not impact blood sugar. So why are we now talking about carbs?

Chapter 3: “I’ll explain why consuming excess carbohydrates – even those that don’t contain gluten – can be just as harmful as eating a gluten-laden diet.” Sigh. Carbs are evil, fat is good. This is just Wheat Belly redux. Also, while I’m in agreement that all fats (with the exception of man-made trans-fats) can be part of a healthy diet and some of us need more (or less) than others, I think we also need to remember that fats contain more calories per gram than other macronutrients. Thus, if weight control is a concern, we must be careful not to consume overly large portions of calorie-dense high-fat foods.

Perlmutter argues that elevated cholesterol is not only not a risk factor for cardiovascular disease, it’s actually protective against CVD, ALS, and other diseases. The primary basis for this claim was a large study in Norway. The researchers found that there was a U-shaped association between total cholesterol and mortality from CVD. This would suggest that cholesterol has an optimal level (between 5.0 and 7.0 mmol L -1). People below 5.0, or at 7.0 or above, were more likely to die from CVD during the course of the study. Interesting indeed. However, those who had CVD at the start of the study were excluded and the researchers didn’t look at the difference between HDL and LDL profiles. I can’t help but wonder if examining these things would have made any difference to the findings. Even assuming their findings are accurate, they still don’t suggest that high levels of serum cholesterol are protective. They merely suggest that both high and low cholesterol may be associated with CVD.

Perlmutter moves on to argue that the use of statins increases the risk of developing Type 2 Diabetes (remind me again how this pertains to grains and gluten being toxic?). He cites a 2012 study that found a 48% increased risk of developing diabetes for women who took statin medications in contrast to women who did not. That sounds huge but it’s actually not as big as it sounds; 9.93% of statin users were diagnosed with DM2 versus 6.41% of non-statin users. This was also an observational study so causal claims cannot be made. While researchers did control for some confounders it’s entirely possible that there was another reason for the relatively greater risk experienced by the statin users, like, oh, say elevated LDL or another related health condition. There was also a large difference in the sample sizes for each group (10, 834 statin users and 143, 006 non-statin users) which makes me leery about drawing precise comparisons.

Chapter 4: Near the end of this chapter Perlmutter cites a 2012 study of weight loss maintenance (he fails to make the maintenance part very clear) as proof positive that a low-carb, high-fat diet is “the best diet for maintaining weight loss.” To be clear, the study had participants lose weight and then put them on one of three possible weight-loss maintenance diets for 4 weeks. They did find that the low-carb diet “produced the greatest improvements in most metabolic syndrome components examined herein” with a couple of caveats: 1. participants also experienced elevated urinary cortisol excretion 2. C-reative protein was found to be higher in this group. So, while some areas, such as resting metabolic rate, were better for participants on this diet, there were also negative effects. In addition, it’s important to note that the sample size was very small, only 21 people. Also, four weeks is not the same as a lifetime. It’s impossible to extrapolate from this experiment that a low-carb, high-fat diet is the optimal diet for health. Nor can we tell if it’s a realistic diet. Even if it does prove to be optimal for health it doesn’t really matter if nearly no one finds it possible to adhere to. I think that Perlmutter is taking it a little too far (yes, I’m being kind) to draw the conclusion that we should all switch from carbs to fats on the basis of this study.

Chapter 5: Perlmutter is making the argument for neurogenesis and discussing the benefits of exercise (I fully support this) as well as caloric restriction (I think the jury’s still out on this one). I do find it interesting that he’s advocating for a high-fat, low-calorie diet. I would think that this would be very difficult to follow; eating small amounts (Perlmutter recommends reducing caloric intake by 30%) of calorie-dense foods likely wouldn’t be very satiating. Just me speculating though.

I can’t help but think that Perlmutter is cherry picking research that supports his hypothesis. Grain Brain reminds me of how I used to write research papers in high school. I would develop an outline, start writing, and find sources that supported my hypothesis to use as citations.

Chapter 6: In this chapter, Perlmutter discusses the possible connection between gluten sensitivity and various mental illnesses; including: depression, autism, tourette’s, and ADHD. Complete with compelling tales of curing patients by placing them on gluten-free diets. While there may be some connection to gluten sensitivity in some of these illnesses (a recent study found a correlation between autism spectrum disorders and positive serologic celiac disease – but not for gut mucosa – test results) I think that without the corresponding evidence that Perlmutter is providing many individuals with false hope. Anecdotal evidence is not the same as scientific evidence and it’s important to note that, in most cases, no link (correlational or causal) has been drawn between gluten and mental illness. That’s not to say that gluten-elimination isn’t worth trying but in the majority of cases it’s unlikely to alleviate symptoms.

I’m reading about how a study of children with celiac disease found an increased risk of headaches of 833% in comparison to the general population. I decided to take a look at the original research Perlmutter cited with the hope of going on a little rant about relative risk (after all, it was 5% of the children in the study with celiac disease who experienced “headache”, versus 0.6% in the general population, still a small minority of children). However, the article that I found that matches the citation by Perlmutter doesn’t contain any such information. In fact, it contains zero mention of celiac disease or gluten whatsoever. Perhaps the citation is mismatched? (Let’s give Perlmutter the benefit of the doubt here). Regardless, it makes it that much more difficult to dispute (or support) his claims when the claims and the citations don’t correspond.

Chapter 7: In this chapter Permutter states, ” many of today’s physicians… don’t have a firm grasp of nutrition and its effects upon your health.” Hear hear! Cue the opportunity to promote the services of registered dietitians. Oh, wait. Perlmutter simply says that he hopes this will change with the next generation of doctors. Sigh. He then goes on to list a number of supplements that apparently we should all be taking.

DHA – Yes, along with EPA in fish oil, this may provide some neurological and cardiovascular benefits (1). Resveratrol – The jury’s still out on this one but more recent research has put a damper on earlier studies praising it as a life-extender (2). Turmeric – This spice is still being researched, and while promising, no conclusions have been reached regarding its benefits. The study Perlmutter cites was epidemiological research which asked residents of Singapore how often they ate curry. Those who ate curry occasionally, often, or very often, performed better on a test of cognitive ability. Of course, there’s potential for missed confounding variables, as well as the possibility that the difference could be attributed to some other component of curry. Probiotics – Again, we are still in the early stages of research linking gut microbiota and brain health. Perlmutter advises against consuming some probiotic foods as they often come with too much sugar. Instead he suggests taking a supplement. As a dietitian, I always think that it’s best to obtain your nutrients from foods whenever possible. Add foods like plain yoghurt, kefir, sauerkraut, miso, and kimchi to your diet to obtain probiotics. Coconut oil – There is some interesting research underway investigating the effects of coconut oil on Alzheimer’s patients (3). I certainly think that it’s a good idea to incorporate a variety of fats in our diets. However, I don’t think that we should go overboard with any one food. Alpha-lipoic Acid – May have some neurological benefits but the research thus far is not strong (4). Vitamin D – It seems like for every positive study regarding vitamin D there’s another study claiming that it’s useless, or even harmful. In our Northern climate, until research shows otherwise, it is still prudent to supplement with Vitamin D during the winter months.

Chapter 8: Shocker: I wholeheartedly agree with everything Perlmutter has to say in this chapter. He is emphasizing the importance of exercise for brain health. Nothing about grains or carbs.

Chapter 9: Another chapter without mention of grains and carbs. Another chapter I actually agree with Perlmutter. Sleep is vitally important for health.

Chapter 10: We’re just getting into general healthy living tips now and recommendations for how to implement the Grain Brain diet. Most of them are perfectly reasonable. Following this, there are some recipes.

As I sat eating birthday cake (it’s birthday season in my family) and contemplating how to conclude this post I commented to my boyfriend, “Who knows, maybe eating cake will give me Alzheimer’s one day.” Considering how few people develop Alzheimer’s disease (14.9% of Canadians over 65 have some form of dementia) and how many people consume grains (statistics unavailable but I’m assuming it’s roughly 100%) based on the current lack of robust evidence it’s a risk I’m willing to take. I hope to celebrate my birthday tomorrow with some cake.

Author: Diana

I'm a registered dietitian from Nova Scotia, living and working in Ontario, Canada. My goal is to help people see food and nutrition from a different perspective and understand that nutrition and health are not necessarily a result of personal choice.

36 thoughts on “Insane in the Grain Brain

  1. Thank you, you may have saved me from reading the bloody copy of this book I purchased 4 months ago. It has been sitting by my bedside table and every time I go to read it, I put it back down. My husband is a vegetarian coeliac, so obviously he avoids all wheat and gluten and all food I prepare for him, is gluten free. (I aim for a varied diet Including buckwheat, brown rice, sorghum, polenta, teff flour etc as well as veggies and tofu and legumes). I like to think of myself as fairly educated about food, in laymans terms, with some cookery training in the past. Personally, as well as gluten free, the kids and I eat spelt, some wheat grains, legumes, veggies, seafood, a little meat, some tofu, some dairy, use olive oil, a little nut oil and coconut oil, some fruit and try to minimise sugar and processed foods. On saying that, I still love butter and desserts and sometimes think what the heck. Surely, home baked goodies are better if we know what actually goes into them, especially when you are feeding children? However, loving food and being aware of all the conflicting information out there sometimes ‘does my head in’. With all the ‘wheat and sugar are killing us zeitgeist’ out there, I thought I should buy his book. Then I think about all the people in the world who have lived to 100 plus on Mediterranean diets and rice based diets and it makes little sense. Sorry to rant. Thanks for the great book review.


    • Thank you so much for the kind comment! It sounds like you’re consuming a healthy diet. I’m glad to have saved you the time you would have wasted reading this book!


  2. okay I’ll admit I didn’t read all of this, BUT the first line discredits Dr.Oz so I just didn’t bother.
    Just going to throw this out there but Dr. Oz, although a sell out to an extent i’m sure, has authored over 400 publications, is a prof at University of Colombia department of surgery, He directs the Cardiovascular Institute and Complementary Medicine Program at New York-Presbyterian Hospital, and has only attended ivy league schools; Harvard for an undergrad and did an MBA and MD simultaneously at UPenn.. sooo I’m going to say he PROBABLY has a better understanding of the body than ANY dietitian you’ll EVER meet..

    Liked by 1 person

  3. Ummmm. No. No no no. This guy is makes me so angry! Gluten has nothing to do with Bipolar Disorder (which is HIGHLY genetic), Depression (a healthy diet can help with recovery but NOT without ACTUAL treatment), ADHD (also HIGHLY genetic), or Autism. Yes, SOME kids with Autism have gastrointestinal issues, so when certain things are removed from their diet, it’s easier for them to focus and concentrate and learn – but it doesn’t cure or cause Autism. ANGER. Thanks for sharing ;)


  4. I just wanted to say that I am enjoying your blog. Your fair-minded and sensible way of viewing things is very helpful. Thanks for all the time and thought you put into your articles!


  5. Great article, Diana! This will give me good ammunition for all the damage control I have to go through as clients read this useless mind-fodder. However, surprised you got past the Dr. Oz endorsement and still had appetite for cake. I usually throw up in my mouth a bit just saying his name.


    • Ahaha. Thank you Roger. I must admit, it was a struggle at times but if I can save at least one other person from reading this book then it will have been worth it!


    • “Useless mind-fodder”

      Is that statement self referential to your own babbling paragraph? Rhetorical question by the way


  6. Incredible — based on many “professionals” who are touting this book as evidence, I am actually surprised at how poorly referenced it is. A semi-side note, I have been surprised lately at some misuse of “essential” as well as it applies to diet. Nice post! I am waiting for my library reserve to come in :)


    • I wasn’t surprised that the studies he cited weren’t great but I was pretty shocked by the reference that contained zero support for the information he claimed it contained. Enjoy!


  7. Gah, every time I visit my parents, I have to dispel Dr Oz crap that my mom hears. Very frustrating. Being a woman of science, i can’t be arsed to even remotely take Grain Brain seriously. People need to eat some bloody veggies and exercise regularly, otherwise, not much chance of a healthy fulfilled life,

    Happy birthday!


  8. Great summary, thank you! As a dietitian myself I also wanted to know what he would have to say but had zero desire to buy the book – now I don’t even have to read it!


  9. Really great post. I’ve been dismissing this book since I first heard of it, given my background in nutritional neuroscience, but I didn’t have the patience to actually read it. Nice to see a thorough breakdown of the good and bad bits, which by the sounds of it would have been the same conclusions I would have made if I could have been bothered to read it myself.


  10. Pingback: This Week in Food, Health, and Fitness | Sheila Kealey

  11. A few things:
    1. “Hells ya” to cake.
    2. Loved the summary.
    3. Dr Oz is ruining my life (and my clients’ lives)
    4. a very HAPPY birthday!



  12. Excellent review of “Grain Brain!” Very well written! I hope millions of people read your review and take it to heart. Too many people are making way-to-much money scaring the general public into believing there is something “wrong” with wheat. Science is on the side of consuming grains such as wheat. I am a registered dietitian in the U.S. I think you should share your review with the Academy of Nutrition and Dietetics – which is the largest professional organization for dietitians in the U.S.A.


  13. Thanks, Diana, for the thoughtful, well-researched post. I suspect you’ll be receiving increased traffic as Public Broadcasting in the States is running an evening-long special with Permutter and his book. I found it troubling that he claimed we all have a 50/50 chance of coming down with Alzheimer’s, when you stated less than 15% of Canadians do. Nothing like scare tactics! Thanks for being a voice of reason!


    • Thanks James! I’ll have to see if the special is shared anywhere online.

      I’m not sure where he would have gotten his 50% Alzheimer’s stat. The one I used was for everyone. He may be only looking at people over a certain age. It’s so easy to manipulate things like that to serve your purpose!

      If you’re interested in learning more about gluten research, stay tuned for a new post tomorrow. :)


    • probably only 15% of canadians have alzhiemer’s now, but a lot more will have to contend with some form of dementia as they age.

      Liked by 1 person

  14. Pingback: Book review: Gluten Freedom | bite my words

  15. Your position is made clear in your opening comments – no open mind and objectivity here. Sometimes I wondered if we were reading the same book. Disappointing that you did not keep your comments to a clinical and considered analysis and allowed people to be persuaded by your argument, rather than eliciting the emotional responses that are seen here.

    Liked by 1 person

  16. Who are you again? What are your qualifications to dis this information? Have you tried his diet recommendations? If not, I think you need to stop this! I have and have been so much healthier! Pain gone, anger controlled , digestion much improved and weight loss are the results I have personally experienced!
    IF anyone is having issues that have not been diagnosed by the “Regular, mainstream” physicians, why wouldn’t you give it a try?! Open your mind and heart to the possibilities of change and good health!


  17. FWIW I was on the Atkins/SouthBeach diet and I also lost weight easily. Unfortunately I also developed kidney stones; during a meeting with my urologist, discussing my diet, when I mentioned these diets, he shook his head. Told me there seemed to be a strong correlation between low carb diets and kidney stones.


  18. I agree that an endorsement from Dr. Oz carries very little weight. However, the thesis that high carb consumption and high blood sugar are not brain friendly is neither new nor particularly controversial. Researchers have been saying for years that Alzheimer’s could just as easily be called “Type 3 Diabetes”. See: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/

    Grain Brain was also endorsed by another MD whose endorsement would be far more significant, if people knew who he was: Dr. Dale E. Bredesen, director of the Easton Center for Alzheimers Research at UCLA Medical School. Dr. Bredesen recently published a peer-reviewed journal article on his success in reversing age related memory loss in 9 out of 10 test subjects with an intensive diet, supplement and exercise protocol. The link to the journal article:

    Click to access 100690.pdf

    The TLDR on the UCLA study is that 9 subjects had been diagnosed with Mild Cognitive Impairment, and 1 had been diagnosed with late stage Alzheimers. The 9 with MCI all improved dramatically, the subject with late stage Alzheimers did not. The cognitive improvements in the 9 responders were so significant that several were able to return to work, after having retired early or gone on disability due to cognitive impairment. The diet, supplementation and lifestyle changes used for the UCLA study are much more rigorous than those recommended in Grain Brain, since they are intended to be remedial rather than preventative. But they are largely parallel, which likely accounts for Dr. Bredesen’s endorsement.

    Part of the UCLA protocol was placing the subjects on a low carb, gluten free diet, and requiring them to fast 12 hours between dinner and breakfast. The dietary restrictions were aimed at sharply reducing the fasting blood sugar, fasting insulin and A1C of the subjects, because so much research indicates that high carb consumption and high blood sugar, (even well below diabetic levels) is a risk factor for dementia. Once again, this is not new information: Perlmutter is just making it accessible to lay people, and providing a great service in doing so. Grains are only part of the carb problem, but presumably “Grain Brain” is a catchier book title than “21st Century Carb Consumption Brain.”

    Liked by 1 person

  19. Diana, you should try the program for a week or two and see what it does for your attention deficit disorder. Take the chip off your shoulder, and risk “wasting” some more time. It might unglue your neurons. I am about to start my wife on the program at her nursing home, where she is currently picking fights with the staff. She got kicked out of the last place, and can’t remember what happened yesterday. What can I lose?


  20. I would think that this would be very difficult to follow; eating small amounts (Perlmutter recommends reducing caloric intake by 30%) of calorie-dense foods likely wouldn’t be very satiating. Just me speculating though.

    500 calories worth of avocados or 500 calories worth of carrots cooked with butter make me feel more satiated than 500 calories of white bread. Fats do make me feel satiated and don’t make me increase my overall calorie intake, but the catch is that I usually eat fats together with vegetables. I feel that my vegetable dishes taste much better with a bit of fats in them.


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